node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C44B12.6 | F25D1.3 | C44B12.6c.1 | F25D1.3.1 | Uncharacterized protein. | Uncharacterized protein. | 0.915 |
C44B12.6 | actl-1 | C44B12.6c.1 | C15B12.6a.1 | Uncharacterized protein. | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | 0.660 |
C44B12.6 | ilcr-1 | C44B12.6c.1 | Y64G10A.6.1 | Uncharacterized protein. | Interleukin cytokine receptor-related protein 1; Forms a receptor complex together with receptor ilcr-2, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. | 0.853 |
C44B12.6 | ilcr-2 | C44B12.6c.1 | F56D1.2.1 | Uncharacterized protein. | Interleukin cytokine receptor-related protein 2; Forms a receptor complex together with receptor ilcr-1, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. | 0.852 |
C44B12.6 | nfki-1 | C44B12.6c.1 | C33A11.1.1 | Uncharacterized protein. | ANK repeat-containing protein nipk-1; Acts downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. Mediates signaling of the complex; Belongs to the iASPP family. | 0.819 |
F25D1.3 | C44B12.6 | F25D1.3.1 | C44B12.6c.1 | Uncharacterized protein. | Uncharacterized protein. | 0.915 |
F25D1.3 | actl-1 | F25D1.3.1 | C15B12.6a.1 | Uncharacterized protein. | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | 0.660 |
F25D1.3 | ilc-17.1 | F25D1.3.1 | T22H6.1.1 | Uncharacterized protein. | Interleukin cytokine-related protein 17.1; Ligand for the receptor complex composed of ilcr-1 and ilcr- 2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones; Belongs to the IL-17 family. | 0.890 |
F25D1.3 | ilcr-1 | F25D1.3.1 | Y64G10A.6.1 | Uncharacterized protein. | Interleukin cytokine receptor-related protein 1; Forms a receptor complex together with receptor ilcr-2, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. | 0.854 |
F25D1.3 | ilcr-2 | F25D1.3.1 | F56D1.2.1 | Uncharacterized protein. | Interleukin cytokine receptor-related protein 2; Forms a receptor complex together with receptor ilcr-1, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. | 0.853 |
F25D1.3 | nfki-1 | F25D1.3.1 | C33A11.1.1 | Uncharacterized protein. | ANK repeat-containing protein nipk-1; Acts downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. Mediates signaling of the complex; Belongs to the iASPP family. | 0.857 |
actl-1 | C44B12.6 | C15B12.6a.1 | C44B12.6c.1 | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | Uncharacterized protein. | 0.660 |
actl-1 | F25D1.3 | C15B12.6a.1 | F25D1.3.1 | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | Uncharacterized protein. | 0.660 |
actl-1 | ilc-17.1 | C15B12.6a.1 | T22H6.1.1 | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | Interleukin cytokine-related protein 17.1; Ligand for the receptor complex composed of ilcr-1 and ilcr- 2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones; Belongs to the IL-17 family. | 0.911 |
actl-1 | ilcr-1 | C15B12.6a.1 | Y64G10A.6.1 | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | Interleukin cytokine receptor-related protein 1; Forms a receptor complex together with receptor ilcr-2, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. | 0.942 |
actl-1 | ilcr-2 | C15B12.6a.1 | F56D1.2.1 | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | Interleukin cytokine receptor-related protein 2; Forms a receptor complex together with receptor ilcr-1, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. | 0.936 |
actl-1 | nfki-1 | C15B12.6a.1 | C33A11.1.1 | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | ANK repeat-containing protein nipk-1; Acts downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. Mediates signaling of the complex; Belongs to the iASPP family. | 0.908 |
actl-1 | pik-1 | C15B12.6a.1 | K09B11.1a.2 | ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | 0.900 |
ikke-1 | nfki-1 | R107.4b.1 | C33A11.1.1 | Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1; Serine/threonine-protein kinase, which plays a role in regulating allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in embryos. Phosphorylates the allophagy receptor allo-1, which is required for allophagy. | ANK repeat-containing protein nipk-1; Acts downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. Mediates signaling of the complex; Belongs to the iASPP family. | 0.769 |
ilc-17.1 | F25D1.3 | T22H6.1.1 | F25D1.3.1 | Interleukin cytokine-related protein 17.1; Ligand for the receptor complex composed of ilcr-1 and ilcr- 2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones; Belongs to the IL-17 family. | Uncharacterized protein. | 0.890 |