STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shn-1Protein shank; Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions. Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca(2+) current density. The maintenance of Ca(2+) also allows for the downstream regulation of Ca(2+)-induced expression of genes such as gem-4. Plays a role in the regulation of the defecation cycle, and this may be in as [...] (1140 aa)    
Predicted Functional Partners:
W03A5.6
Uncharacterized protein.
   
 0.884
ras-1
GTP binding protein.
  
 
 0.878
ras-2
GTP binding protein.
  
 
 0.874
F20D6.8
Uncharacterized protein.
  
 
 0.874
drn-1
GTP-binding protein drn-1; Displays low GTPase activity and exists predominantly in the GTP-bound form (By similarity). Together with epac-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.
  
 
 0.871
pix-1
PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog.
    
 
 0.871
rap-3
RAP homolog (Vertebrate Rap GTPase family).
  
 
 0.870
ssr-2
Sperm-Specific family, class R.
  
 
 0.870
rap-2
RAP homolog (Vertebrate Rap GTPase family).
  
 
 0.870
rap-1
Ras-related protein Rap-1; Required in the hypodermis for proper formation of the cuticle; Belongs to the small GTPase superfamily. Ras family.
  
 
 0.870
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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