STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dyc-1Dystrophin-like protein 1; Together with dys-1 and hlh-1, participates in a common muscular function. (887 aa)    
Predicted Functional Partners:
dys-1
Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning.
   
 
 0.958
dyb-1
Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance.
   
 
 0.909
stn-1
Syntrophin-1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance.
   
 0.906
zyx-1
Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development.
   
 
 0.904
sgn-1
SarcoGlycaN.
   
 
 0.866
sgcb-1
SarcoGlyCan Beta homolog.
   
 
 0.842
sgca-1
CADG domain-containing protein.
   
 
 0.792
stn-2
PDZ domain-containing protein.
   
 
 0.788
uig-1
PH domain-containing protein.
   
  
 0.776
mtrr-1
Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state.
    
 
 0.735
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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