STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-162Nuclear Hormone Receptor family. (347 aa)    
Predicted Functional Partners:
nhr-268
Nuclear hormone receptor family member nhr-268; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
      
 0.888
nhr-274
NR LBD domain-containing protein.
      
 0.888
dap-3
Mammalian cell Death Associated Protein related.
    
 
 0.857
R02E12.4
Uncharacterized protein.
   
  
 0.850
nas-18
Zinc metalloproteinase nas-18; Metalloprotease.
      
 0.811
nhr-120
Nuclear Hormone Receptor family.
   
  
 0.804
athp-1
AT Hook plus PHD finger transcription factor.
      
 0.691
cdh-5
CaDHerin family.
      
 0.549
Y59A8B.12
Uncharacterized protein.
      
 0.537
wnk-1
Serine/threonine-protein kinase WNK; Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals.
      
 0.461
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.