STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rsu-1Ras SUppressor homolog. (268 aa)    
Predicted Functional Partners:
unc-97
LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.
   
 0.998
pat-4
Integrin-linked protein kinase homolog pat-4; Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc- 112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromus [...]
   
 
 0.988
pat-6
Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...]
   
 
 0.913
pin-2
LIM domain-containing protein pin-2.
   
 
 0.909
C06A8.6
LRRcap domain-containing protein.
  
   
 0.902
oig-4
Immunoglobulin domain-containing protein oig-4; Required for the localization of acetylcholine receptors at neuromuscular junctions and for subsequently controlling the response evoked by receptor stimulation.
      
 0.697
lat-1
Latrophilin-like protein 1; Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    
   0.636
plrg-1
WD_REPEATS_REGION domain-containing protein.
    
 
 0.625
sds-22
Protein phosphatase 1 regulatory subunit SDS22 homolog; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family.
  
   
 0.613
rap-3
RAP homolog (Vertebrate Rap GTPase family).
    
 
 0.602
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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