STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C34F11.5Tyrosine-protein kinase. (894 aa)    
Predicted Functional Partners:
plc-3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation [...]
   
  0.742
R07E5.6
Uncharacterized protein.
   
    0.688
T08B6.4
Uncharacterized protein.
   
   0.661
T27A3.5
Tyrosine-protein phosphatase.
   
   0.659
F13A7.1
Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
   
   0.656
T22C1.8
Tyrosine-protein phosphatase.
   
   0.655
W03F11.4
Protein-tyrosine-phosphatase.
   
   0.651
F44G3.7
Uncharacterized protein; Belongs to the serpin family.
   
   0.648
ssq-4
Sperm-Specific family, class Q.
   
   0.642
W02B12.12
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 
0.642
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (14%) [HD]