STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C35D10.12Methyltransf_11 domain-containing protein. (365 aa)    
Predicted Functional Partners:
C04H5.1
Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both RNA and protein methyltransferases.
   
 
 0.772
spat-1
Suppressor of PAr-Two defect.
   
 
 0.772
Y54E10BR.4
RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.
   
 
 0.567
Y71F9AL.1
UPF0020 domain-containing protein.
   
 
 0.529
rps-30
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
   0.478
efsc-1
Tr-type G domain-containing protein.
   
 0.471
eif-2gamma
Tr-type G domain-containing protein.
   
 0.471
elpc-3
Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...]
   
 
 0.456
W08F4.3
Uncharacterized protein.
   
 0.446
tut-2
Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position.
   
  
 0.434
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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