node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Y40A1A.2 | meg-1 | Y40A1A.2.1 | K02B9.1.1 | Uncharacterized protein. | Uncharacterized protein. | 0.692 |
Y40A1A.2 | meg-4 | Y40A1A.2.1 | C36C9.1.1 | Uncharacterized protein. | Uncharacterized protein. | 0.758 |
ZK1067.2 | glh-4 | ZK1067.2b.1 | T12F5.3.1 | NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. | ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. | 0.580 |
ZK1067.2 | meg-4 | ZK1067.2b.1 | C36C9.1.1 | NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. | Uncharacterized protein. | 0.758 |
ZK1067.2 | mut-16 | ZK1067.2b.1 | B0379.3a.1 | NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. | MUTator. | 0.900 |
ZK1067.2 | pgl-1 | ZK1067.2b.1 | ZK381.4b.1 | NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. | Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] | 0.765 |
ZK1067.2 | pgl-3 | ZK1067.2b.1 | C18G1.4a.1 | NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. | Guanyl-specific ribonuclease pgl-3; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. P-granule component involved in germline development. Together with the P-granule component pgl-1, is involved in the formation of P-granules. Together with pgl- 1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules. In vitro, binds mRNA; this interaction [...] | 0.622 |
glh-4 | ZK1067.2 | T12F5.3.1 | ZK1067.2b.1 | ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. | NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. | 0.580 |
glh-4 | meg-4 | T12F5.3.1 | C36C9.1.1 | ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. | Uncharacterized protein. | 0.711 |
glh-4 | pgl-1 | T12F5.3.1 | ZK381.4b.1 | ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. | Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] | 0.953 |
glh-4 | pgl-3 | T12F5.3.1 | C18G1.4a.1 | ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. | Guanyl-specific ribonuclease pgl-3; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. P-granule component involved in germline development. Together with the P-granule component pgl-1, is involved in the formation of P-granules. Together with pgl- 1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules. In vitro, binds mRNA; this interaction [...] | 0.961 |
glh-4 | pptr-1 | T12F5.3.1 | W08G11.4.1 | ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. | Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1; Probable regulatory subunit of serine/threonine-protein phosphatase let-92 which negatively regulates the insulin receptor signaling cascade composed of daf-2, age-1, akt-1, akt-2 and sgk-1 by promoting the dephosphorylation of akt-1 on 'Thr-350'. Negatively regulates several functions controlled by the insulin pathway including dauer formation, lifespan, fat storage and stress resistance. Plays a role in the asymmetric segregation of the P granule components during embryonic cell divisions but does not play an essentia [...] | 0.556 |
meg-1 | Y40A1A.2 | K02B9.1.1 | Y40A1A.2.1 | Uncharacterized protein. | Uncharacterized protein. | 0.692 |
meg-1 | meg-2 | K02B9.1.1 | K02B9.2.1 | Uncharacterized protein. | Uncharacterized protein. | 0.587 |
meg-1 | meg-4 | K02B9.1.1 | C36C9.1.1 | Uncharacterized protein. | Uncharacterized protein. | 0.787 |
meg-1 | pgl-1 | K02B9.1.1 | ZK381.4b.1 | Uncharacterized protein. | Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] | 0.693 |
meg-1 | pptr-1 | K02B9.1.1 | W08G11.4.1 | Uncharacterized protein. | Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1; Probable regulatory subunit of serine/threonine-protein phosphatase let-92 which negatively regulates the insulin receptor signaling cascade composed of daf-2, age-1, akt-1, akt-2 and sgk-1 by promoting the dephosphorylation of akt-1 on 'Thr-350'. Negatively regulates several functions controlled by the insulin pathway including dauer formation, lifespan, fat storage and stress resistance. Plays a role in the asymmetric segregation of the P granule components during embryonic cell divisions but does not play an essentia [...] | 0.515 |
meg-1 | pptr-2 | K02B9.1.1 | C13G3.3c.1 | Uncharacterized protein. | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. | 0.465 |
meg-2 | meg-1 | K02B9.2.1 | K02B9.1.1 | Uncharacterized protein. | Uncharacterized protein. | 0.587 |
meg-2 | meg-4 | K02B9.2.1 | C36C9.1.1 | Uncharacterized protein. | Uncharacterized protein. | 0.795 |