node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
irx-1 | myrf-2 | C36F7.1.1 | F21A10.2e.1 | Putative iroquois-class homeodomain protein irx-1. | Myelin regulatory factor homolog 2, C-terminal; [Myelin regulatory factor homolog 2]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 2, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] | 0.833 |
irx-1 | oig-1 | C36F7.1.1 | C09E7.3.1 | Putative iroquois-class homeodomain protein irx-1. | Immunoglobulin domain-containing protein oig-1; Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons. Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr- 12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation. | 0.807 |
irx-1 | sox-3 | C36F7.1.1 | F40E10.2.1 | Putative iroquois-class homeodomain protein irx-1. | HMG box domain-containing protein. | 0.778 |
irx-1 | sox-4 | C36F7.1.1 | C12D12.5b.1 | Putative iroquois-class homeodomain protein irx-1. | HMG box domain-containing protein. | 0.762 |
irx-1 | spp-19 | C36F7.1.1 | K04A8.9.1 | Putative iroquois-class homeodomain protein irx-1. | Activin_recp domain-containing protein. | 0.808 |
irx-1 | ttr-39 | C36F7.1.1 | C04G2.1a.1 | Putative iroquois-class homeodomain protein irx-1. | TransThyretin-Related family domain. | 0.810 |
irx-1 | unc-120 | C36F7.1.1 | D1081.2.1 | Putative iroquois-class homeodomain protein irx-1. | MADS-box domain-containing protein. | 0.810 |
irx-1 | unc-30 | C36F7.1.1 | B0564.10b.1 | Putative iroquois-class homeodomain protein irx-1. | Homeobox protein unc-30; Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid- secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of gene [...] | 0.679 |
irx-1 | unc-55 | C36F7.1.1 | F55D12.4a.1 | Putative iroquois-class homeodomain protein irx-1. | Nuclear hormone receptor unc-55; Acts as a transcriptional regulator. Required for ventral D (VD) motor neurons to adopt their normal synaptic pattern. Suppresses expression of flp-13 in VD motor neurons to ensure formation of the correct synaptic pattern. Maintains low cAMP levels in VD motor neurons by enhancing expression of pde-4 which hydrolyzes cAMP and repressing expression of acy-1 which catalyzes cAMP formation. This prevents respecification of synapses by VD neurons. During copulation, required in males for correct movement of the spicules, a pair of prong-like structures whi [...] | 0.854 |
irx-1 | unc-8 | C36F7.1.1 | R13A1.4c.1 | Putative iroquois-class homeodomain protein irx-1. | Degenerin unc-8. | 0.696 |
myrf-2 | irx-1 | F21A10.2e.1 | C36F7.1.1 | Myelin regulatory factor homolog 2, C-terminal; [Myelin regulatory factor homolog 2]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 2, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] | Putative iroquois-class homeodomain protein irx-1. | 0.833 |
myrf-2 | oig-1 | F21A10.2e.1 | C09E7.3.1 | Myelin regulatory factor homolog 2, C-terminal; [Myelin regulatory factor homolog 2]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 2, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] | Immunoglobulin domain-containing protein oig-1; Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons. Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr- 12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation. | 0.461 |
oig-1 | irx-1 | C09E7.3.1 | C36F7.1.1 | Immunoglobulin domain-containing protein oig-1; Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons. Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr- 12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation. | Putative iroquois-class homeodomain protein irx-1. | 0.807 |
oig-1 | myrf-2 | C09E7.3.1 | F21A10.2e.1 | Immunoglobulin domain-containing protein oig-1; Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons. Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr- 12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation. | Myelin regulatory factor homolog 2, C-terminal; [Myelin regulatory factor homolog 2]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 2, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] | 0.461 |
oig-1 | unc-30 | C09E7.3.1 | B0564.10b.1 | Immunoglobulin domain-containing protein oig-1; Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons. Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr- 12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation. | Homeobox protein unc-30; Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid- secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of gene [...] | 0.810 |
oig-1 | unc-55 | C09E7.3.1 | F55D12.4a.1 | Immunoglobulin domain-containing protein oig-1; Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons. Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr- 12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation. | Nuclear hormone receptor unc-55; Acts as a transcriptional regulator. Required for ventral D (VD) motor neurons to adopt their normal synaptic pattern. Suppresses expression of flp-13 in VD motor neurons to ensure formation of the correct synaptic pattern. Maintains low cAMP levels in VD motor neurons by enhancing expression of pde-4 which hydrolyzes cAMP and repressing expression of acy-1 which catalyzes cAMP formation. This prevents respecification of synapses by VD neurons. During copulation, required in males for correct movement of the spicules, a pair of prong-like structures whi [...] | 0.801 |
sox-3 | irx-1 | F40E10.2.1 | C36F7.1.1 | HMG box domain-containing protein. | Putative iroquois-class homeodomain protein irx-1. | 0.778 |
sox-3 | sox-4 | F40E10.2.1 | C12D12.5b.1 | HMG box domain-containing protein. | HMG box domain-containing protein. | 0.552 |
sox-3 | unc-30 | F40E10.2.1 | B0564.10b.1 | HMG box domain-containing protein. | Homeobox protein unc-30; Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid- secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of gene [...] | 0.484 |
sox-4 | irx-1 | C12D12.5b.1 | C36F7.1.1 | HMG box domain-containing protein. | Putative iroquois-class homeodomain protein irx-1. | 0.762 |