STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ceh-36Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. (257 aa)    
Predicted Functional Partners:
mls-2
Homeobox domain-containing protein.
   
  
 0.829
che-1
Transcription factor che-1; Transcription factor essential for the identity of ASE chemosensory neurons. Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase. Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36.
    
 
 0.816
odr-7
Nuclear hormone receptor family member odr-7; Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity.
      
 0.812
str-2
Seven transmembrane receptor 2.
      
 0.807
gcy-5
Receptor-type guanylate cyclase gcy-5; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses to salt ions mediated by ASE sensory neurons.
      
 0.807
lim-4
Putative transcription factor LIM-4.
   
 
 0.768
odr-1
Receptor-type guanylate cyclase gcy-10; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward volatile odorants in AWC sensory neurons and their avoidance in AWB sensory neurons. May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Involved in phototransduction in ASJ neurons downstream of G protein coupled-photoreceptor lite-1. Required to maintain the expression of putative olfactory receptor str-2 in AWC neurons in adults. In AWB and AWC sensory neurons, media [...]
      
 0.743
tax-2
Cyclic nucleotide-binding domain-containing protein.
   
  
 0.719
ceh-27
Homeobox domain-containing protein.
   
  
 0.716
lim-6
LIM domain family.
    
 
 0.699
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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