STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ceh-37Homeobox protein ceh-37; Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1.5 repeats for binding. Bends telomeric DNA and may provide chromosome stability. Also required for development of AWB olfactory neurons; Belongs to the paired homeobox family. (278 aa)    
Predicted Functional Partners:
T12E12.3
Uncharacterized protein.
      
 0.768
R06A4.2
Uncharacterized protein.
      
 0.739
mxt-1
Eukaryotic translation initiation factor 4E-binding protein Mextli homolog; Plays a role in promoting translation.
   
  
 0.666
hmg-5
HMG box domain-containing protein.
      
 0.664
plp-1
Pur alpha Like Protein.
      
 0.623
lin-11
Protein lin-11; Probable transcription factor which is required for asymmetric division of vulval blast cells. Involved in olfactory plasticity probably by regulating the expression of transcription factor mbr-1 in RIF neurons. Plays a role in the chemorepulsive response toward ascaroside pheromones mediated by the ADL sensory neurons, probably by regulating E-box motif 5'-CANNTG-3' containing target genes in the ADL neurons. Plays a role in the differentiation of the ADL sensory neurons.
   
 
 0.602
nhr-119
Nuclear Hormone Receptor family.
      
 0.542
zfh-2
Zinc Finger and Homeobox.
      
 0.532
fbxa-183
F-box domain-containing protein.
      
 0.531
mop-25.2
MO25-like protein 2; Regulates asymmetric cell division in Q.p neuroblast lineage. Plays a role in cell shedding during embryogenesis.
      
 0.530
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.