STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
abhd-5.2Abhydrolase domain-containing protein abhd-5.2; Acts coordinately with phospholipase atgl-1 within the lipolytic cascade to distribute stored energy to tissues to maintain energy levels during the dauer phase. Localizes atgl-1 to lipid droplets, possibly to facilitate triglyceride hydrolysis. Regulates lipid droplet size, lipid content, the exchange of lipids between lipid droplets and fusion of lipid droplets during the dauer phase. Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. (444 aa)    
Predicted Functional Partners:
hosl-1
Uncharacterized protein.
  
 
 0.914
atgl-1
Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...]
    
 
 0.887
dgat-2
Acyl-CoA:DiacylGlycerol AcylTransferase.
   
  
 0.875
pks-1
PolyKetide Synthase.
  
 
 0.849
acl-1
Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
   
  
 0.736
kin-1
cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
   
  
 0.733
K01A2.5
AB hydrolase-1 domain-containing protein.
      
 0.726
lpin-1
LNS2 domain-containing protein.
   
  
 0.702
plin-1
Perilipin-1 homolog; Lipid droplet-associated protein which plays a role in lipid droplet clustering. Belongs to the perilipin family.
   
  
 0.669
F37C12.3
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
  
 0.626
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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