STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tag-325WW domain-containing protein tag-325. (840 aa)    
Predicted Functional Partners:
rho-1
Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...]
   
 0.759
fcho-1
FCH domain Only (FCH stands for Fes/CIP4 homology domain).
   
 
 0.750
gei-1
START domain-containing protein.
    
0.698
chw-1
CHp/Wrch Rho-like protein homolog.
   
 0.692
cdc-42
Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...]
   
 0.642
rga-8
Rho-GAP domain-containing protein.
   
 
0.639
rga-6
Rho-GAP domain-containing protein.
   
 
0.635
ced-10
Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...]
   
 0.630
rac-2
Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation.
   
 0.630
rga-1
Rho-GAP domain-containing protein.
   
 
0.626
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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