STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
unc-105Degenerin-like protein unc-105; Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (962 aa)    
Predicted Functional Partners:
del-7
DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
     
 0.849
degt-1
DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
 
 0.816
cca-1
Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]
   
  
 0.775
del-8
DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
     
 0.738
acd-3
Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.733
unc-9
Innexin unc-9; Structural component of the gap junctions. Belongs to the pannexin family.
   
  
 0.716
let-2
Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development.
   
  
 0.678
trp-4
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.668
del-3
DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.660
del-5
DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
 
 0.638
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.