STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eri-7Enhanced RNAI (RNA interference). (625 aa)    
Predicted Functional Partners:
eri-6
Enhanced RNAI (RNA interference).
   
  
 0.950
rnp-5
RRM domain-containing protein.
   
  
 0.823
C41D11.6
Uncharacterized protein.
      
 0.816
K09B11.4
Uncharacterized protein.
      
 0.805
eri-5
Tudor domain-containing protein.
   
  
 0.805
ergo-1
Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...]
   
  
 0.717
mut-16
MUTator.
   
  
 0.707
R02D3.8
Exonuclease domain-containing protein.
   
  
 0.707
eri-1
3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi.
   
  
 0.672
drh-3
Dicer Related Helicase.
   
  
 0.609
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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