node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arr-1 | egl-30 | F53H8.2.1 | M01D7.7a.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | Heterotrimeric G protein alpha subunit. | 0.574 |
arr-1 | gnrr-4 | F53H8.2.1 | C41G11.4c.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.922 |
arr-1 | gpb-1 | F53H8.2.1 | F13D12.7a.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | 0.593 |
arr-1 | gpb-2 | F53H8.2.1 | F52A8.2a.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.654 |
arr-1 | gpc-1 | F53H8.2.1 | K02A4.2.3 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.584 |
arr-1 | gpc-2 | F53H8.2.1 | F08B6.2.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | G protein gamma domain-containing protein. | 0.492 |
arr-1 | grk-2 | F53H8.2.1 | W02B3.2.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | G protein-coupled receptor kinase 2; Specifically phosphorylates the activated forms of G protein- coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis. Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations. Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin. Acts in head acetylcholine neurons to pos [...] | 0.761 |
arr-1 | gsa-1 | F53H8.2.1 | R06A10.2a.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | G protein, Subunit Alpha. | 0.427 |
egl-30 | arr-1 | M01D7.7a.1 | F53H8.2.1 | Heterotrimeric G protein alpha subunit. | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | 0.574 |
egl-30 | gnrr-4 | M01D7.7a.1 | C41G11.4c.1 | Heterotrimeric G protein alpha subunit. | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.609 |
egl-30 | gpa-12 | M01D7.7a.1 | F18G5.3.1 | Heterotrimeric G protein alpha subunit. | Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families. Upstream of plc-3, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. | 0.663 |
egl-30 | gpa-18 | M01D7.7a.1 | W03F8.9b.1 | Heterotrimeric G protein alpha subunit. | G Protein, Alpha subunit. | 0.627 |
egl-30 | gpb-1 | M01D7.7a.1 | F13D12.7a.1 | Heterotrimeric G protein alpha subunit. | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | 0.991 |
egl-30 | gpb-2 | M01D7.7a.1 | F52A8.2a.1 | Heterotrimeric G protein alpha subunit. | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.986 |
egl-30 | gpc-1 | M01D7.7a.1 | K02A4.2.3 | Heterotrimeric G protein alpha subunit. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.978 |
egl-30 | gpc-2 | M01D7.7a.1 | F08B6.2.1 | Heterotrimeric G protein alpha subunit. | G protein gamma domain-containing protein. | 0.966 |
egl-30 | grk-2 | M01D7.7a.1 | W02B3.2.1 | Heterotrimeric G protein alpha subunit. | G protein-coupled receptor kinase 2; Specifically phosphorylates the activated forms of G protein- coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis. Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations. Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin. Acts in head acetylcholine neurons to pos [...] | 0.888 |
egl-30 | gsa-1 | M01D7.7a.1 | R06A10.2a.1 | Heterotrimeric G protein alpha subunit. | G protein, Subunit Alpha. | 0.684 |
gnrr-4 | arr-1 | C41G11.4c.1 | F53H8.2.1 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | 0.922 |
gnrr-4 | egl-30 | C41G11.4c.1 | M01D7.7a.1 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Heterotrimeric G protein alpha subunit. | 0.609 |