node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D1054.3 | rbx-1 | D1054.3a.1 | ZK287.5.2 | SGS domain-containing protein. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.445 |
D1054.3 | rbx-2 | D1054.3a.1 | R10A10.2.1 | SGS domain-containing protein. | RING-type domain-containing protein. | 0.409 |
D1054.3 | skr-16 | D1054.3a.1 | C42D4.6.1 | SGS domain-containing protein. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.535 |
D1054.3 | skr-21 | D1054.3a.1 | K08H2.1.1 | SGS domain-containing protein. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.501 |
T28B4.1 | cul-1 | T28B4.1c.1 | D2045.6.1 | F-box domain-containing protein. | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | 0.817 |
T28B4.1 | cul-6 | T28B4.1c.1 | K08E7.7a.1 | F-box domain-containing protein. | Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.817 |
T28B4.1 | rbx-1 | T28B4.1c.1 | ZK287.5.2 | F-box domain-containing protein. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.850 |
T28B4.1 | skpt-1 | T28B4.1c.1 | F48E8.7a.1 | F-box domain-containing protein. | F-box domain-containing protein. | 0.410 |
T28B4.1 | skr-16 | T28B4.1c.1 | C42D4.6.1 | F-box domain-containing protein. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.526 |
T28B4.1 | skr-21 | T28B4.1c.1 | K08H2.1.1 | F-box domain-containing protein. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.526 |
crls-1 | skr-16 | F23H11.9a.1 | C42D4.6.1 | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.545 |
crls-1 | skr-21 | F23H11.9a.1 | K08H2.1.1 | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.533 |
cul-1 | T28B4.1 | D2045.6.1 | T28B4.1c.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | F-box domain-containing protein. | 0.817 |
cul-1 | cul-6 | D2045.6.1 | K08E7.7a.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.907 |
cul-1 | lin-23 | D2045.6.1 | K10B2.1b.2 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). | 0.989 |
cul-1 | rbx-1 | D2045.6.1 | ZK287.5.2 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.999 |
cul-1 | rbx-2 | D2045.6.1 | R10A10.2.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | RING-type domain-containing protein. | 0.992 |
cul-1 | skpt-1 | D2045.6.1 | F48E8.7a.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | F-box domain-containing protein. | 0.990 |
cul-1 | skr-16 | D2045.6.1 | C42D4.6.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.995 |
cul-1 | skr-21 | D2045.6.1 | K08H2.1.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.995 |