STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C43H6.4Uncharacterized protein. (627 aa)    
Predicted Functional Partners:
epc-1
Enhancer of PolyComb-like.
   
 
 0.945
B0025.4
Uncharacterized protein.
    
 
 0.941
ekl-4
Uncharacterized protein.
    
 
 0.929
trr-1
Transcription-associated protein 1; Influences germ cell fate in hermaphrodites. Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote expression of fog-3 and control male tail development (By similarity). Involved in the negative regulation of vulval development. Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
    
 
 0.918
mrg-1
MRG domain-containing protein.
   
 
 0.896
C17E4.6
YL1_C domain-containing protein.
   
 
 0.800
eri-12
Enhanced RNAI (RNA interference).
   
  
 0.791
cec-7
C.Elegans Chromodomain protein.
   
 
 0.781
swsn-6
SWI/SNF nucleosome remodeling complex component; Belongs to the actin family.
   
 
 0.779
ssl-1
Helicase ssl-1; Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
    
 
 0.746
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.