STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
chil-10Glyco_hydro_18 domain-containing protein. (371 aa)    
Predicted Functional Partners:
efhc-1
EF-Hand domain-Containing protein 1 homolog.
    
 
 0.552
cope-1
Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
   
    0.513
idh-2
Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
   
    0.487
C27C12.4
Uncharacterized protein.
   
    0.482
pcrg-1
Parkin Co-Regulated Gene (PACRG) homolog.
    
 
 0.460
hsp-6
Heat shock 70 kDa protein F, mitochondrial; Belongs to the heat shock protein 70 family.
    
   0.459
C54C6.6
Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility; Belongs to the CFAP20 family.
    
   0.459
mig-10
Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family.
    
   0.459
coh-1
Rad21_Rec8 domain-containing protein.
   
 
 0.454
scc-1
Sister chromatid cohesion protein 1; Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity).
    
 
 0.452
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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