STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lron-1LRRCT domain-containing protein. (607 aa)    
Predicted Functional Partners:
pax-1
Paired domain-containing protein.
   
  
 0.808
lat-1
Latrophilin-like protein 1; Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    
   0.715
iglr-2
Immunoglobulin domain and leucine-rich repeat-containing protein 2.
      
 0.664
let-413
Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...]
  
 
 
 0.523
lrch-1
Calponin-homology (CH) domain-containing protein.
  
   0.517
ZK546.2
Uncharacterized protein.
  
     0.490
let-4
Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance.
  
  
0.477
lron-15
ELRR (Extracellular Leucine-Rich Repeat) ONly.
  
  
0.475
pan-1
P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation.
  
  
0.442
rsu-1
Ras SUppressor homolog.
  
 
   0.441
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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