STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
let-4Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. (773 aa)    
Predicted Functional Partners:
sym-1
SYM-1 protein.
  
  
0.999
wrt-10
WaRThog (Hedgehog-like family).
   
    0.999
noah-1
NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A).
   
 
 0.923
lpr-3
LiPocalin-Related protein.
   
  
 0.921
let-653
Protein let-653; Required for epithelial tube development and shaping. Involved in the morphogenesis and function of the three unicellular tubes of the excretory system, the canal cell, the duct cell and the pore cell. Also plays a role in cuticle development, alae formation and shaping of the vulval lumen. Required for larval development.
   
  
 0.910
noah-2
NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A).
   
 
 0.887
fbn-1
FiBrilliN homolog.
   
 
 0.875
lpr-1
LiPocalin-Related protein.
   
  
 0.866
lpr-6
LiPocalin-Related protein.
   
    0.846
mua-3
Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton.
   
 
 0.750
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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