STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C46C2.2MFS domain-containing protein. (520 aa)    
Predicted Functional Partners:
F54D1.6
Uncharacterized protein F54D1.6.
   
  
 0.812
otub-3
OTU domain-containing protein.
   
  
 0.809
cyld-1
USP domain-containing protein.
   
  
 0.803
usp-50
USP domain-containing protein; Belongs to the peptidase C19 family.
      
 0.758
F07A11.4
Ubiquitin carboxyl-terminal hydrolase.
   
  
 0.713
cyk-3
Ubiquitin carboxyl-terminal hydrolase cyk-3; Ubiquitin-protein hydrolase which cleaves ubiquitin from ubiquitinated proteins. Plays a role in embryo osmoregulation. Probably by regulating osmosis, controls actin redistribution in the 1-cell embryos and thus actin-dependent processes such as cytokinesis and P-granules segregation. During the first embryonic mitotic division, involved in the formation of a functional microtubule organizing center provided by the male pronucleus ; Belongs to the peptidase C19 family.
   
  
 0.703
H34C03.2
Ubiquitin carboxyl-terminal hydrolase.
   
  
 0.702
hsp-43
SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.
      
 0.700
M01G12.9
Uncharacterized protein.
      
 0.699
prp-8
Pre-mRNA-splicing factor 8 homolog; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
   
  
 0.698
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.