STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgp-9p-GlycoProtein related. (1294 aa)    
Predicted Functional Partners:
abt-6
ABC Transporter family.
  
 
 0.740
sup-17
Disintegrin and metalloproteinase domain-containing protein 10 homolog; Metalloprotease (By similarity). Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification. By modulating lin-12/Notch signaling, plays a role in germline development. Probably by modulating BMP-like Sma/Mab signaling via the shedding of unc-40 ectodomain, involved in the regulation of body size and mesoderm development. Probably b [...]
      
 0.678
lgc-37
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
 
 0.677
avr-14
Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
      
 0.668
pgp-11
p-GlycoProtein related.
  
 
0.661
pgp-10
p-GlycoProtein related.
  
 
0.653
pgp-3
Multidrug resistance protein pgp-3; Mediates ATP-dependent export of organic anions and xenobiotics from the cytoplasm. Hydrolyzes ATP with low efficiency (By similarity); Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
  
 
0.643
pgp-14
P-glycoprotein related (146.8 kD) (Pgp-14).
  
 
0.631
pgp-13
p-GlycoProtein related.
  
 
0.625
pgp-12
p-GlycoProtein related.
  
 
0.614
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.