STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
deg-1Degenerin deg-1; Probable sodium channel subunit. Required by a subset of neurons. (778 aa)    
Predicted Functional Partners:
degt-1
DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
     
 0.876
trp-4
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.853
del-7
DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
     
 0.806
deg-3
Acetylcholine receptor subunit alpha-type deg-3; Subunit of the non-synaptic neuronal acetylcholine receptor, which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
      
 0.801
del-9
DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
     
 0.787
del-5
DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
     
 0.758
osm-9
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.702
mec-6
Mechanosensory abnormality protein 6; Probable touch-cell sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Interacts with degenerin channel proteins and stabilizes the channel. Non-voltage- gated amiloride-sensitive cation channel permeable for sodium, potassium, lithium and N-methylglucamine. Belongs to the paraoxonase family.
   
  
 0.699
trpa-1
Transient receptor potential cation channel subfamily A member 1 homolog; Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors.
   
  
 0.693
mec-2
Mechanosensory protein 2; Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons.
   
 
 0.691
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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