STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C47E12.3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (568 aa)    
Predicted Functional Partners:
ZC506.1
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
  
 
0.938
F10C2.5
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
  
 
0.920
tag-353
Ubiquitin-like domain-containing protein.
   
  
 0.879
Y56A3A.2
Peptidase_M50 domain-containing protein.
      
 0.855
sel-1
Suppressor/Enhancer of Lin-12.
   
 
 0.830
calu-1
CALUmenin (Calcium-binding protein) homolog.
   
  
 0.812
cdkr-3
CDK5RAP3-like protein; Potential regulator of CDK5 activity.
   
  
 0.812
rer-1
Protein RER1 homolog; May be involved in protein transport along the secretory pathway; Belongs to the RER1 family.
      
 0.807
sel-11
E3 ubiquitin-protein ligase hrd-1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play [...]
   
 
 0.773
nucb-1
NUCleoBindin homolog.
      
 0.759
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.