STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-167Nuclear hormone receptor family member nhr-167; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (343 aa)    
Predicted Functional Partners:
hlh-10
BHLH domain-containing protein.
  
    0.542
hlh-4
Helix-loop-helix protein 4; Acts as a transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Required for the correct morphology, terminal identity and function of the ADL sensory neurons by controlling the expression of the ADL-specific gene repertoire, including chemoreceptor encoding genes, ion channel encoding genes, neuropeptides and the neurotransmitter eat-4. Regulates the expression of the srh-234 chemoreceptor encoding gene in the ADL neurons under feeding conditions. Plays a role in the chemorepulsive response toward asca [...]
  
     0.515
npr-12
G_PROTEIN_RECEP_F1_2 domain-containing protein.
  
     0.480
ceh-6
Homeobox protein ceh-6; Vital for embryonic development and essential for the proper function of the excretory cell. Required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development.
  
 
   0.457
npr-7
G_PROTEIN_RECEP_F1_2 domain-containing protein.
  
    0.426
npr-24
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
  
     0.417
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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