STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ets-8ETS domain-containing protein. (141 aa)    
Predicted Functional Partners:
ets-9
ETS domain-containing protein.
      
 0.699
egl-38
Paired domain-containing protein.
  
 
 0.680
pax-2
Paired domain-containing protein.
  
 
 0.680
gcy-36
Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...]
      
 0.660
npax-4
Paired domain-containing protein.
  
 
 0.652
nhr-192
Nuclear Hormone Receptor family.
  
   0.567
daf-14
MH2 domain-containing protein.
  
 
 0.564
daf-8
Dwarfin sma.
  
 
 0.562
nhr-2
Nuclear hormone receptor family member nhr-2; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
  
   0.559
srt-58
Nuclear receptor domain-containing protein.
  
   0.553
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.