STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lgc-48Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (366 aa)    
Predicted Functional Partners:
acr-23
Betaine receptor acr-23; Betaine receptor that functions as a ligand-gated non- selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion. The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions. Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA.
  
  
 0.736
clh-2
Chloride channel protein.
   
  
 0.622
acr-20
AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
  
 0.605
clh-4
Chloride channel protein.
   
  
 0.590
lev-8
Uncharacterized protein.
  
   
 0.545
des-2
Acetylcholine receptor subunit alpha-type des-2; Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  
   
 0.544
acr-8
Acetylcholine receptor 8.
  
   
 0.527
acr-24
AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
   
 0.519
deg-3
Acetylcholine receptor subunit alpha-type deg-3; Subunit of the non-synaptic neuronal acetylcholine receptor, which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
  
   
 0.509
lgc-25
Neur_chan_LBD domain-containing protein.
  
     0.507
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.