STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bath-42BTB and MATH domain-containing protein 42; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (410 aa)    
Predicted Functional Partners:
cil-1
Inositol polyphosphate 5-phosphatase; Dephosphorylates a number of phosphatidylinositols. Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate. Has a role in sperm activation and motility. Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2; Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
 
    
 0.918
cul-3
Cullin-3; Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule st [...]
   
 0.879
bath-1
BTB and MATH domain containing.
   
 
 0.825
bath-21
BTB domain-containing protein.
    
 
 0.820
bath-24
BTB and MATH domain containing.
    
 
 0.819
BE0003N10.3
UBR-type domain-containing protein.
   
  
 0.819
reps-1
REPS (RalBP1-associated Eps domain-containing protein) homolog.
    
 
 0.777
flh-1
FLYWCH-type domain-containing protein.
   
  
 0.735
sel-5
Serine/threonine-protein kinase sel-5; Serine/threonine-protein kinase which may play a role in lin- 12-mediated cell-fate decisions.
   
  
 0.706
M02B7.7
Uncharacterized protein.
   
   0.647
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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