STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C50D2.1Uncharacterized protein. (576 aa)    
Predicted Functional Partners:
asd-2
RNA-binding protein asd-2; RNA-binding protein that binds to the 5'-NACUAAY-N(1,20)- UAAY-3' consensus sequence in pre-mRNA introns to promote alternative splicing. Required for mutually exclusive alternative splicing where it modulates the switch between mutually exclusive exons during pre-mRNA maturation. Involved in muscle-specific gene expression regulating the alternative splicing of genes such as let-2 and unc-60 to ensure that their respective isoforms are expressed in muscle. Promotes the removal of intron 10 from let-2 pre-mRNA to allow for the exclusive expression of the musc [...]
   
  
 0.746
osr-1
Osmotic stress resistance protein.
   
  
 0.735
emb-5
Suppressor of Ty 6 homolog; May regulate transcriptional elongation by RNA polymerase II. Required for several aspects of morphogenesis of C.elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate; Belongs to the SPT6 family.
      
 0.697
gpdh-2
Probable glycerol-3-phosphate dehydrogenase 2.
      
 0.692
C38C6.3
Uncharacterized protein.
   
    0.592
K04F10.3
Endoplasmic reticulum-like protein.
      
 0.572
spn-4
RRM domain-containing protein.
    
 
 0.563
ZC123.1
Uncharacterized protein.
   
    0.557
grl-5
Ground-like domain-containing protein.
   
    0.538
lit-1
Serine/threonine kinase NLK; Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T- cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction. Plays a role in male tail tip morphogenesis.
   
 
 0.493
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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