STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
klo-1KLOtho (Mammalian aging-associated protein) homolog; Belongs to the glycosyl hydrolase 1 family. (479 aa)    
Predicted Functional Partners:
aagr-1
P-type domain-containing protein; Belongs to the glycosyl hydrolase 31 family.
  
 0.931
egl-15
Myoblast growth factor receptor egl-15; Receptor tyrosine kinase required for larval development. May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2. May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1. Acts in the hypodermis to regulate axon growth and fluid homeostasis. Activates protein degradation in muscles. Probably following interaction with ligand let-756, regulates negatively membrane protrusion from body wall muscles during larval develop [...]
   
 
 0.879
klo-2
KLOtho (Mammalian aging-associated protein) homolog; Belongs to the glycosyl hydrolase 1 family.
  
  
0.806
zipt-15
Zrt (ZRT), Irt-(IRT-) like Protein Transporter.
      
 0.806
C14F11.6
Uncharacterized protein.
  
 
 0.786
agl-1
AGL (Amylo-1,6-GLucosidase, 4-alpha-glucanotransferase) glycogen debranching enzyme.
     
 0.785
egl-17
EGL-17; Belongs to the heparin-binding growth factors family.
    
 
 0.770
let-756
Protein let-756; Required for larval development. Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development.
    
 
 0.678
ppt-1
Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.
     
 0.498
F18F11.1
PeroXisomal Membrane Protein homolog.
   
  
 0.495
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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