node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arl-8 | klc-1 | Y57G11C.13.1 | M7.2b.1 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. | TPR_REGION domain-containing protein. | 0.777 |
arl-8 | klc-2 | Y57G11C.13.1 | C18C4.10b.1 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | 0.795 |
arl-8 | snb-1 | Y57G11C.13.1 | T10H9.4.1 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. | 0.408 |
arl-8 | syd-2 | Y57G11C.13.1 | F59F5.6.1 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. | 0.758 |
arl-8 | unc-104 | Y57G11C.13.1 | C52E12.2b.2 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] | 0.900 |
arl-8 | unc-16 | Y57G11C.13.1 | ZK1098.10e.1 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] | 0.470 |
elks-1 | rab-3 | F42A6.9.1 | C18A3.6a.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | 0.876 |
elks-1 | snb-1 | F42A6.9.1 | T10H9.4.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. | 0.812 |
elks-1 | syd-2 | F42A6.9.1 | F59F5.6.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. | 0.982 |
elks-1 | unc-10 | F42A6.9.1 | T10A3.1a.1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] | 0.984 |
elks-1 | unc-104 | F42A6.9.1 | C52E12.2b.2 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] | 0.765 |
klc-1 | arl-8 | M7.2b.1 | Y57G11C.13.1 | TPR_REGION domain-containing protein. | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. | 0.777 |
klc-1 | klc-2 | M7.2b.1 | C18C4.10b.1 | TPR_REGION domain-containing protein. | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | 0.820 |
klc-1 | unc-104 | M7.2b.1 | C52E12.2b.2 | TPR_REGION domain-containing protein. | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] | 0.810 |
klc-1 | unc-16 | M7.2b.1 | ZK1098.10e.1 | TPR_REGION domain-containing protein. | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] | 0.850 |
klc-2 | arl-8 | C18C4.10b.1 | Y57G11C.13.1 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. | 0.795 |
klc-2 | klc-1 | C18C4.10b.1 | M7.2b.1 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | TPR_REGION domain-containing protein. | 0.820 |
klc-2 | syd-2 | C18C4.10b.1 | F59F5.6.1 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. | 0.439 |
klc-2 | unc-104 | C18C4.10b.1 | C52E12.2b.2 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] | 0.870 |
klc-2 | unc-16 | C18C4.10b.1 | ZK1098.10e.1 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] | 0.984 |