STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyl-1Cyclin L; Belongs to the cyclin family. (480 aa)    
Predicted Functional Partners:
cdk-11.1
Cyclin-dependent kinase 11.1; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Important for normal oocyte and sperm development; probably required during multiple stages of gametogenesis. Plays a role in the activation of RAS-ERK signaling in the germ line. Also acts partially redundantly with cdk-11.2 to ensure embryonic viability. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
   
 
 0.906
cdk-11.2
Cyclin-dependent kinase 11.2; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Acts partially redundantly with cdk-11.1 to ensure embryonic viability. In contrast to cdk-11.1, not essential for male and female fertility.
   
 
 0.845
W04G5.9
PAW domain-containing protein.
      
 0.807
Y49F6B.8
Uncharacterized protein.
      
 0.807
srxa-19
7TM_GPCR_Srx domain-containing protein.
      
 0.804
D1054.10
Uncharacterized protein.
      
 0.804
F07C6.2
Uncharacterized protein.
      
 0.804
cutl-6
ZP domain-containing protein.
      
 0.804
Y116A8C.30
Uncharacterized protein.
      
 0.804
lmd-2
LysM domain-containing protein.
      
 0.800
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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