node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aap-1 | akt-2 | Y110A7A.10.1 | F28H6.1a.1 | Phosphoinositide 3-kinase adapter subunit. | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | 0.982 |
aap-1 | ftt-2 | Y110A7A.10.1 | F52D10.3a.3 | Phosphoinositide 3-kinase adapter subunit. | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 0.607 |
aap-1 | ist-1 | Y110A7A.10.1 | C54D1.3b.1 | Phosphoinositide 3-kinase adapter subunit. | Insulin receptor SubsTrate homolog. | 0.696 |
aap-1 | par-5 | Y110A7A.10.1 | M117.2a.1 | Phosphoinositide 3-kinase adapter subunit. | 14-3-3-like protein 1. | 0.464 |
aap-1 | pdk-1 | Y110A7A.10.1 | H42K12.1b.1 | Phosphoinositide 3-kinase adapter subunit. | 3-phosphoinositide-dependent protein kinase 1; Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. | 0.876 |
akt-2 | aap-1 | F28H6.1a.1 | Y110A7A.10.1 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | Phosphoinositide 3-kinase adapter subunit. | 0.982 |
akt-2 | ftt-2 | F28H6.1a.1 | F52D10.3a.3 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 0.683 |
akt-2 | ist-1 | F28H6.1a.1 | C54D1.3b.1 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | Insulin receptor SubsTrate homolog. | 0.643 |
akt-2 | par-5 | F28H6.1a.1 | M117.2a.1 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | 14-3-3-like protein 1. | 0.579 |
akt-2 | pdk-1 | F28H6.1a.1 | H42K12.1b.1 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | 3-phosphoinositide-dependent protein kinase 1; Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. | 0.978 |
fkh-7 | ist-1 | F26D12.1a.1 | C54D1.3b.1 | Fork-head domain-containing protein. | Insulin receptor SubsTrate homolog. | 0.496 |
ftt-2 | aap-1 | F52D10.3a.3 | Y110A7A.10.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | Phosphoinositide 3-kinase adapter subunit. | 0.607 |
ftt-2 | akt-2 | F52D10.3a.3 | F28H6.1a.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | 0.683 |
ftt-2 | ist-1 | F52D10.3a.3 | C54D1.3b.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | Insulin receptor SubsTrate homolog. | 0.702 |
ftt-2 | par-5 | F52D10.3a.3 | M117.2a.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 14-3-3-like protein 1. | 0.658 |
ftt-2 | pdk-1 | F52D10.3a.3 | H42K12.1b.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 3-phosphoinositide-dependent protein kinase 1; Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. | 0.640 |
hsb-1 | ist-1 | K08E7.2.4 | C54D1.3b.1 | Heat Shock factor Binding protein. | Insulin receptor SubsTrate homolog. | 0.586 |
ins-17 | ins-18 | F56F3.6.3 | T28B8.2.2 | Insulin-like peptide 17; Involved in the regulation of the larval diapause. | INSulin related. | 0.737 |
ins-17 | ist-1 | F56F3.6.3 | C54D1.3b.1 | Insulin-like peptide 17; Involved in the regulation of the larval diapause. | Insulin receptor SubsTrate homolog. | 0.479 |
ins-18 | ins-17 | T28B8.2.2 | F56F3.6.3 | INSulin related. | Insulin-like peptide 17; Involved in the regulation of the larval diapause. | 0.737 |