STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
test-1Thyroglobulin type-1 domain-containing protein. (234 aa)    
Predicted Functional Partners:
cex-2
Calexcitin-2.
   
  
 0.720
ttbk-5
Protein kinase domain-containing protein.
   
  
 0.699
ost-1
SPARC; Has a high affinity for collagen. Affects nematode body morphology and mobility. Essential for C.elegans development and muscle function. The cysteine-rich region could have protease inhibitory activity or may provide the framework for a protein binding module. Probable role in skeletal morphogenesis; Belongs to the SPARC family.
   
  
 0.698
cdr-3
CaDmium Responsive.
      
 0.683
ugt-1
UDP-GlucuronosylTransferase.
      
 0.667
F08H9.4
SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.
      
 0.660
dur-1
Dauer Up-Regulated.
   
  
 0.636
F08H9.3
SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.
      
 0.632
ctb-1
Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c (By similarity). Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
      
 0.631
cyp-33C9
CYtochrome P450 family; Belongs to the cytochrome P450 family.
   
  
 0.617
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.