STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CC8.2Protein phosphatase 1 regulatory subunit. (318 aa)    
Predicted Functional Partners:
gsy-1
Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Belongs to the glycosyltransferase 3 family.
   
 
 0.813
K10D2.8
Uncharacterized protein.
    
 0.657
H18N23.2
Protein phosphatase 1 regulatory subunit.
  
 
 
0.628
nprl-3
GATOR complex protein NPRL3; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
   
 
 0.546
pygl-1
Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
   
 
 0.505
Y104H12D.2
Uncharacterized protein.
   
   0.469
Y32H12A.7
ABC1 domain-containing protein.
   
    0.463
cogc-3
Conserved Oligomeric Golgi (COG) Component.
   
    0.463
ppm-1.A
Protein phosphatase ppm-1.A; Probable phosphatase which regulates axon termination in ALM and PLM neurons, and synaptic branch extension and/or stabilization in PLM neurons. Plays a role in synapse formation in GABAergic DD motor neurons probably by dephosphorylating pmk-3 thereby negatively regulating a MAP kinase pathway that includes dlk-1, mkk-4 and pmk-3. Belongs to the PP2C family.
   
 
 0.460
plr-1
Probable E3 ubiquitin-protein ligase plr-1; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non- canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG. Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the [...]
   
    0.457
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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