node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F10C2.4 | cps-6 | F10C2.4.1 | C41D11.8.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | 0.532 |
F10C2.4 | crn-1 | F10C2.4.1 | Y47G6A.8.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.995 |
F10C2.4 | crn-2 | F10C2.4.1 | CD4.2.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Cell death-related nuclease 2. | 0.699 |
F10C2.4 | crn-4 | F10C2.4.1 | AH9.2.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing. | 0.812 |
F10C2.4 | crn-5 | F10C2.4.1 | C14A4.5.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | RNase_PH domain-containing protein. | 0.779 |
F54B8.4 | crn-2 | F54B8.4b.1 | CD4.2.1 | Uncharacterized protein. | Cell death-related nuclease 2. | 0.790 |
cps-6 | F10C2.4 | C41D11.8.1 | F10C2.4.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | 0.532 |
cps-6 | crn-1 | C41D11.8.1 | Y47G6A.8.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.947 |
cps-6 | crn-2 | C41D11.8.1 | CD4.2.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Cell death-related nuclease 2. | 0.766 |
cps-6 | crn-4 | C41D11.8.1 | AH9.2.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing. | 0.890 |
cps-6 | crn-5 | C41D11.8.1 | C14A4.5.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | RNase_PH domain-containing protein. | 0.873 |
crn-1 | F10C2.4 | Y47G6A.8.1 | F10C2.4.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | 0.995 |
crn-1 | cps-6 | Y47G6A.8.1 | C41D11.8.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | 0.947 |
crn-1 | crn-2 | Y47G6A.8.1 | CD4.2.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Cell death-related nuclease 2. | 0.715 |
crn-1 | crn-4 | Y47G6A.8.1 | AH9.2.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing. | 0.902 |
crn-1 | crn-5 | Y47G6A.8.1 | C14A4.5.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RNase_PH domain-containing protein. | 0.903 |
crn-2 | F10C2.4 | CD4.2.1 | F10C2.4.1 | Cell death-related nuclease 2. | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | 0.699 |
crn-2 | F54B8.4 | CD4.2.1 | F54B8.4b.1 | Cell death-related nuclease 2. | Uncharacterized protein. | 0.790 |
crn-2 | cps-6 | CD4.2.1 | C41D11.8.1 | Cell death-related nuclease 2. | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | 0.766 |
crn-2 | crn-1 | CD4.2.1 | Y47G6A.8.1 | Cell death-related nuclease 2. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.715 |