STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
D1022.4DLH domain-containing protein. (243 aa)    
Predicted Functional Partners:
hphd-1
Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
  
 
 0.725
F32D1.5
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
   
 
 0.437
B0272.3
Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
   
 
 0.417
ech-3
Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.
   
 
 0.415
hacd-1
Hydroxy-Acyl-CoA Dehydrogenase.
   
 
 0.415
alh-12
Aldedh domain-containing protein.
   
 
  0.408
alh-1
Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.
   
 
  0.407
ech-7
Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.
   
 
 0.405
ech-4
ACB domain-containing protein.
  
 
 0.402
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.