STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nekl-4Serine/threonine-protein kinase D1044.8. (981 aa)    
Predicted Functional Partners:
klp-13
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.740
mlt-4
ANK_REP_REGION domain-containing protein.
   
 
 0.727
ccpp-1
Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells.
   
 
 0.724
ttll-11
Tubulin polyglutamylase ttll-11; Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating. [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP c [...]
   
  
 0.706
ttll-15
Probable tubulin polyglutamylase ttll-15; Probable polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins. Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family.
      
 0.698
mlt-2
ANK_REP_REGION domain-containing protein.
   
 
 0.692
ttll-5
Tubulin polyglutamylase ttll-5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Together with ttll-4 and ttll-11, required for male mating. Probably by regulating microtubule stability via the glutamylation of tubulin, negatively regulates axon regrowth after injury in PLM neurons.
      
 0.692
mlt-3
ANK_REP_REGION domain-containing protein.
   
 
 0.692
ttll-4
Tubulin polyglutamylase ttll-4; Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia. Together with ttll-5 and ttll-11, required for male mating.
      
 0.660
klp-4
Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.530
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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