STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trk-1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (840 aa)    
Predicted Functional Partners:
trf-1
TNF Receptor Associated Factor (TRAF) homolog.
   
 
 0.791
pgrn-1
ProGRaNulin homolog.
    
 
 0.696
mig-2
Rac-like GTPase.
   
 0.602
ksr-2
Kinase suppressor of Ras B; Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation. Plays a role in meiotic recombination events. Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells.
  
   0.555
R151.1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.
  
 
0.555
kin-24
Tyrosine-protein kinase.
  
 
 
0.528
Y116A8C.24
Tyrosine-protein kinase.
  
 
 
0.522
Y116A8C.38
Tyrosine-protein kinase.
  
 
 
0.521
C03B1.5
Putative tyrosine-protein kinase C03B1.5.
  
 
 
 0.504
kgb-2
Mitogen-activated protein kinase.
  
   0.497
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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