STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdc-5LCell Division Cycle related. (755 aa)    
Predicted Functional Partners:
plrg-1
WD_REPEATS_REGION domain-containing protein.
   
 0.999
prp-19
Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family.
   
 0.999
syf-1
SYF pre-mRNA splicing factor homolog.
   
 0.998
M03F8.3
Uncharacterized protein.
   
 0.998
cwc-15
Spliceosome-associated protein CWC15 homolog; Component of a spliceosomal complex that is required for activating pre-mRNA splicing.
   
 0.998
isy-1
Protein isy-1; Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10. Does not affect the splicing of zip-10 ; Belongs to the ISY1 family.
   
 0.997
syf-2
Pre-mRNA-splicing factor syf-2; May be involved in pre-mRNA splicing.
   
 0.997
rbm-22
RNA Binding Motif protein homolog.
   
 0.996
skp-1
Uncharacterized protein T27F2.1.
   
 
 0.996
let-858
Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family.
   
 
 0.995
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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