STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zhp-2RING-type domain-containing protein. (240 aa)    
Predicted Functional Partners:
zhp-4
Zip (Yeast meiotic zipper) Homologous Protein.
   
  
 0.966
Y39B6A.1
Uncharacterized protein.
      
 0.859
msh-5
MutS protein homolog 5; Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks.
   
 
 0.762
syp-1
Synaptonemal complex protein SYP-1.
   
  
 0.758
cosa-1
CrossOver Site Associated.
   
  
 0.747
zhp-1
Zip (Yeast meiotic zipper) Homologous Protein.
   
 
0.731
htp-1
HORMA domain-containing protein.
   
  
 0.725
rec-8
Meiotic recombination protein rec-8; Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co- orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division. Belongs to the rad21 family. Highly divergent.
   
  
 0.687
syp-2
Uncharacterized protein.
   
  
 0.659
dsb-2
Double-Strand Break factor.
   
  
 0.652
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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