node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
csa-1 | csb-1 | D2013.3.1 | F53H4.1.1 | Cockayne Syndrome complementation group A homolog. | CSB (Cockayne Syndrome B) homolog. | 0.974 |
csa-1 | cul-4 | D2013.3.1 | F45E12.3.1 | Cockayne Syndrome complementation group A homolog. | Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. | 0.843 |
csa-1 | ddb-1 | D2013.3.1 | M18.5.1 | Cockayne Syndrome complementation group A homolog. | DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. | 0.869 |
csa-1 | msh-2 | D2013.3.1 | H26D21.2.1 | Cockayne Syndrome complementation group A homolog. | DNA_MISMATCH_REPAIR_2 domain-containing protein. | 0.716 |
csa-1 | rbx-1 | D2013.3.1 | ZK287.5.2 | Cockayne Syndrome complementation group A homolog. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.841 |
csa-1 | skih-2 | D2013.3.1 | F01G4.3.1 | Cockayne Syndrome complementation group A homolog. | SKI (Yeast SuperKIller) Helicase homolog. | 0.711 |
csa-1 | ttc-37 | D2013.3.1 | Y47A7.1.1 | Cockayne Syndrome complementation group A homolog. | TeTratriCopeptide repeat domain protein related. | 0.743 |
csa-1 | uvs-1 | D2013.3.1 | ZK742.2.1 | Cockayne Syndrome complementation group A homolog. | UV-stimulated scaffold protein A homolog; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity). Belongs to the UVSSA family. | 0.822 |
csa-1 | xpa-1 | D2013.3.1 | K07G5.2.1 | Cockayne Syndrome complementation group A homolog. | XPA_C domain-containing protein. | 0.952 |
csa-1 | xpc-1 | D2013.3.1 | Y76B12C.2.1 | Cockayne Syndrome complementation group A homolog. | XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog. | 0.929 |
csb-1 | csa-1 | F53H4.1.1 | D2013.3.1 | CSB (Cockayne Syndrome B) homolog. | Cockayne Syndrome complementation group A homolog. | 0.974 |
csb-1 | cul-4 | F53H4.1.1 | F45E12.3.1 | CSB (Cockayne Syndrome B) homolog. | Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. | 0.606 |
csb-1 | ddb-1 | F53H4.1.1 | M18.5.1 | CSB (Cockayne Syndrome B) homolog. | DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. | 0.846 |
csb-1 | msh-2 | F53H4.1.1 | H26D21.2.1 | CSB (Cockayne Syndrome B) homolog. | DNA_MISMATCH_REPAIR_2 domain-containing protein. | 0.540 |
csb-1 | rbx-1 | F53H4.1.1 | ZK287.5.2 | CSB (Cockayne Syndrome B) homolog. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.518 |
csb-1 | uvs-1 | F53H4.1.1 | ZK742.2.1 | CSB (Cockayne Syndrome B) homolog. | UV-stimulated scaffold protein A homolog; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity). Belongs to the UVSSA family. | 0.887 |
csb-1 | xpa-1 | F53H4.1.1 | K07G5.2.1 | CSB (Cockayne Syndrome B) homolog. | XPA_C domain-containing protein. | 0.967 |
csb-1 | xpc-1 | F53H4.1.1 | Y76B12C.2.1 | CSB (Cockayne Syndrome B) homolog. | XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog. | 0.984 |
cul-4 | csa-1 | F45E12.3.1 | D2013.3.1 | Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. | Cockayne Syndrome complementation group A homolog. | 0.843 |
cul-4 | csb-1 | F45E12.3.1 | F53H4.1.1 | Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. | CSB (Cockayne Syndrome B) homolog. | 0.606 |