STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dhhc-14Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (565 aa)    
Predicted Functional Partners:
nhr-52
Nuclear hormone receptor family member nhr-52; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
   
  
 0.813
unc-93
Putative potassium channel regulatory protein unc-93; May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord ; Belongs to the unc-93 family.
      
 0.583
nphp-2
ANK_REP_REGION domain-containing protein.
  
 
   0.516
F21G4.6
Uncharacterized protein.
    
 
 0.504
mel-11
ANK_REP_REGION domain-containing protein.
  
 
 0.489
gfi-2
ANK_REP_REGION domain-containing protein.
  
   0.488
mlt-3
ANK_REP_REGION domain-containing protein.
  
 
   0.485
fem-1
Sex-determining protein fem-1; Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. Substrate recognition subunit of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin- protein ligase complex which mediates in association with cofactors fem-2 and fem-3 the ubiquitination and subsequent proteasomal degradation of tra-1.
  
 
   0.484
F26F4.12
ANK_REP_REGION domain-containing protein.
  
   0.480
unc-97
LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.
    
 
 0.475
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.