STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyc-1Pyruvate carboxylase 1; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1175 aa)    
Predicted Functional Partners:
men-1
Malic enzyme.
   
 0.997
cts-1
Probable citrate synthase, mitochondrial.
  
 0.995
pccb-1
Propionyl Coenzyme A Carboxylase Beta subunit.
 
 0.993
gdh-1
Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 
 0.991
icl-1
Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family.
  
 0.989
F02A9.10
Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism; Belongs to the AccD/PCCB family.
 
 0.987
mdh-2
Probable malate dehydrogenase, mitochondrial.
  
 0.986
ldh-1
L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. LDH family.
  
 0.984
pck-2
Phosphoenolypyruvate CarboxyKinase.
   
 
 0.984
mdh-1
Malate dehydrogenase.
  
 0.982
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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