node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D2085.7 | atg-3 | D2085.7a.1 | Y55F3AM.4a.1 | Uncharacterized protein. | Autophagy-related protein 3. | 0.447 |
D2085.7 | atg-5 | D2085.7a.1 | Y71G12B.12a.1 | Uncharacterized protein. | Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] | 0.443 |
D2085.7 | atg-7 | D2085.7a.1 | M7.5.1 | Uncharacterized protein. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 0.533 |
D2085.7 | atg-9 | D2085.7a.1 | T22H9.2a.1 | Uncharacterized protein. | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. | 0.465 |
D2085.7 | epg-7 | D2085.7a.1 | T08A9.1.1 | Uncharacterized protein. | ATG11 domain-containing protein. | 0.471 |
D2085.7 | epg-9 | D2085.7a.1 | Y69A2AR.7a.1 | Uncharacterized protein. | Ectopic P Granules. | 0.475 |
D2085.7 | lgg-1 | D2085.7a.1 | C32D5.9.1 | Uncharacterized protein. | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | 0.478 |
D2085.7 | lgg-3 | D2085.7a.1 | B0336.8.1 | Uncharacterized protein. | Ubiquitin-like protein atg-12; Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin- like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg- 3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg- 3-atg-16 complex, required for lgg-1 lipidation; the comple [...] | 0.550 |
D2085.7 | vps-15 | D2085.7a.1 | ZK930.1a.1 | Uncharacterized protein. | Related to yeast Vacuolar Protein Sorting factor. | 0.470 |
D2085.7 | vps-34 | D2085.7a.1 | B0025.1a.1 | Uncharacterized protein. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] | 0.457 |
atg-3 | D2085.7 | Y55F3AM.4a.1 | D2085.7a.1 | Autophagy-related protein 3. | Uncharacterized protein. | 0.447 |
atg-3 | atg-5 | Y55F3AM.4a.1 | Y71G12B.12a.1 | Autophagy-related protein 3. | Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] | 0.999 |
atg-3 | atg-7 | Y55F3AM.4a.1 | M7.5.1 | Autophagy-related protein 3. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 0.999 |
atg-3 | atg-9 | Y55F3AM.4a.1 | T22H9.2a.1 | Autophagy-related protein 3. | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. | 0.978 |
atg-3 | epg-7 | Y55F3AM.4a.1 | T08A9.1.1 | Autophagy-related protein 3. | ATG11 domain-containing protein. | 0.837 |
atg-3 | epg-9 | Y55F3AM.4a.1 | Y69A2AR.7a.1 | Autophagy-related protein 3. | Ectopic P Granules. | 0.790 |
atg-3 | lgg-1 | Y55F3AM.4a.1 | C32D5.9.1 | Autophagy-related protein 3. | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | 0.998 |
atg-3 | lgg-3 | Y55F3AM.4a.1 | B0336.8.1 | Autophagy-related protein 3. | Ubiquitin-like protein atg-12; Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin- like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg- 3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg- 3-atg-16 complex, required for lgg-1 lipidation; the comple [...] | 0.999 |
atg-3 | vps-15 | Y55F3AM.4a.1 | ZK930.1a.1 | Autophagy-related protein 3. | Related to yeast Vacuolar Protein Sorting factor. | 0.984 |
atg-3 | vps-34 | Y55F3AM.4a.1 | B0025.1a.1 | Autophagy-related protein 3. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] | 0.985 |