STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptb-1Putative RNA-binding protein PTB-1a. (615 aa)    
Predicted Functional Partners:
hrpk-1
Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response.
   
 0.856
hrpl-1
Heterogeneous nuclear RibonucleoProtein (HnRNP) L homolog.
  
0.845
hrpf-1
HnRNP F homolog.
   
 0.836
hrp-1
Heterogeneous nuclear ribonucleoprotein A1; This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan.
   
 0.833
rsp-8
RRM domain-containing protein.
   
 0.801
T13C2.6
EGF-like domain-containing protein.
      
 0.766
sym-2
RNA-binding protein sym-2; mRNA splicing factor that regulates alternative splicing of many genes in embryo. Probably plays a role in the formation of embryo- specific isoforms; Belongs to the ESRP family.
   
  
 0.711
rsp-6
Probable splicing factor, arginine/serine-rich 6; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood; Belongs to the splicing factor SR family.
   
 
 0.703
C06A6.4
M20_dimer domain-containing protein.
      
 0.693
exc-7
Uncharacterized protein.
   
 
 0.693
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.