STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
let-504Nkap_C domain-containing protein. (504 aa)    
Predicted Functional Partners:
K01G5.8
Uncharacterized protein.
   
 0.938
F37A4.2
Uncharacterized protein F37A4.2.
   
 0.935
F53F4.14
Sde2_N_Ubi domain-containing protein.
   
 0.934
K07C5.6
Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Belongs to the SLU7 family.
   
 0.923
let-858
Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family.
   
  0.922
T23G11.4
Uncharacterized protein.
   
 
  0.919
H31G24.3
BTB domain-containing protein.
   
  
 0.908
cir-1
Cir_N domain-containing protein.
   
 
 0.905
sacy-1
Suppressor of ACY-4 sterility; Belongs to the DEAD box helicase family.
   
  0.896
syf-2
Pre-mRNA-splicing factor syf-2; May be involved in pre-mRNA splicing.
   
  0.892
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.