node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
emb-27 | rbg-3 | F10B5.6.1 | B0393.2.2 | Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] | Rab-GAP TBC domain-containing protein. | 0.443 |
emb-27 | tbc-14 | F10B5.6.1 | E01G4.1b.1 | Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] | Rab-GAP TBC domain-containing protein. | 0.576 |
emb-27 | tbc-20 | F10B5.6.1 | Y54E2A.12a.1 | Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] | Rab-GAP TBC domain-containing protein. | 0.558 |
fis-1 | fndc-1 | F41G3.4.1 | T06D8.7.1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. | 0.714 |
fis-1 | lgg-1 | F41G3.4.1 | C32D5.9.1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | 0.543 |
fis-1 | tbc-14 | F41G3.4.1 | E01G4.1b.1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | Rab-GAP TBC domain-containing protein. | 0.874 |
fis-2 | fndc-1 | F13B9.8b.1 | T06D8.7.1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. | 0.425 |
fis-2 | lgg-1 | F13B9.8b.1 | C32D5.9.1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | 0.540 |
fis-2 | tbc-14 | F13B9.8b.1 | E01G4.1b.1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | Rab-GAP TBC domain-containing protein. | 0.942 |
fndc-1 | fis-1 | T06D8.7.1 | F41G3.4.1 | FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | 0.714 |
fndc-1 | fis-2 | T06D8.7.1 | F13B9.8b.1 | FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | 0.425 |
fndc-1 | lgg-1 | T06D8.7.1 | C32D5.9.1 | FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | 0.972 |
fndc-1 | tbc-14 | T06D8.7.1 | E01G4.1b.1 | FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. | Rab-GAP TBC domain-containing protein. | 0.771 |
gdi-1 | rab-7 | Y57G11C.10b.1 | W03C9.3.2 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | RAB family. | 0.979 |
gdi-1 | tbc-14 | Y57G11C.10b.1 | E01G4.1b.1 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Rab-GAP TBC domain-containing protein. | 0.566 |
lgg-1 | fis-1 | C32D5.9.1 | F41G3.4.1 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | 0.543 |
lgg-1 | fis-2 | C32D5.9.1 | F13B9.8b.1 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. | 0.540 |
lgg-1 | fndc-1 | C32D5.9.1 | T06D8.7.1 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. | 0.972 |
lgg-1 | rab-7 | C32D5.9.1 | W03C9.3.2 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | RAB family. | 0.898 |
lgg-1 | rbg-3 | C32D5.9.1 | B0393.2.2 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | Rab-GAP TBC domain-containing protein. | 0.468 |