node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
E02D9.1 | F46E10.2 | E02D9.1a.1 | F46E10.2.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 5H1. | 0.811 |
E02D9.1 | H17B01.2 | E02D9.1a.1 | H17B01.2.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Uncharacterized protein. | 0.810 |
E02D9.1 | Y106G6A.1 | E02D9.1a.1 | Y106G6A.1.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein. | 0.950 |
E02D9.1 | dsbn-1 | E02D9.1a.1 | Y106G6A.5a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the dysbindin family. | 0.771 |
E02D9.1 | ksr-1 | E02D9.1a.1 | F13B9.5.2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Kinase suppressor of Ras A; Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Functions redundantly with ksr-2 in the Ras-mediated regulation of larval survival, the development of excretory canal and in mpk-1 phosphorylation in somatic cells. In addition, involved in determining vulval precursor cell fate during vulval induction i [...] | 0.902 |
E02D9.1 | ksr-2 | E02D9.1a.1 | F58D5.4a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Kinase suppressor of Ras B; Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation. Plays a role in meiotic recombination events. Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells. | 0.913 |
E02D9.1 | lin-45 | E02D9.1a.1 | Y73B6A.5b.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Positively regulates lifespan upstream of mek-2 and mpk-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. | 0.944 |
E02D9.1 | mek-2 | E02D9.1a.1 | Y54E10BL.6.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | 0.827 |
E02D9.1 | mpk-1 | E02D9.1a.1 | F43C1.2b.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] | 0.862 |
E02D9.1 | pes-4 | E02D9.1a.1 | Y119D3B.17.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Patterned Expression Site. | 0.801 |
F46E10.2 | E02D9.1 | F46E10.2.1 | E02D9.1a.1 | 5H1. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.811 |
F46E10.2 | H17B01.2 | F46E10.2.1 | H17B01.2.1 | 5H1. | Uncharacterized protein. | 0.850 |
H17B01.2 | E02D9.1 | H17B01.2.1 | E02D9.1a.1 | Uncharacterized protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.810 |
H17B01.2 | F46E10.2 | H17B01.2.1 | F46E10.2.1 | Uncharacterized protein. | 5H1. | 0.850 |
Y106G6A.1 | E02D9.1 | Y106G6A.1.1 | E02D9.1a.1 | Protein kinase domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.950 |
Y106G6A.1 | mek-2 | Y106G6A.1.1 | Y54E10BL.6.1 | Protein kinase domain-containing protein. | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | 0.806 |
Y106G6A.1 | mpk-1 | Y106G6A.1.1 | F43C1.2b.1 | Protein kinase domain-containing protein. | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] | 0.523 |
dsbn-1 | E02D9.1 | Y106G6A.5a.1 | E02D9.1a.1 | Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the dysbindin family. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.771 |
dsbn-1 | mek-2 | Y106G6A.5a.1 | Y54E10BL.6.1 | Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the dysbindin family. | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | 0.771 |
dsbn-1 | mpk-1 | Y106G6A.5a.1 | F43C1.2b.1 | Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the dysbindin family. | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] | 0.499 |